Experiments on mice proved metformin longevity - BBC Chinese net

August 27, 2013 – 14:25

Laboratory rats Low dose of the American Framingham mice can extend life.

Last a scientific journal "Nature Communications" published a study showed that diabetes drug metformin (also known as America metformin) can extend the life of male mice.

Scientists believe that metformin may have a similar effect of extreme calorie restriction method, the method is restricted dietary intake of calories, it is thought to contribute to health and longevity.

Baltimore, Maryland, National Institute on Aging, said Dr. Rafael Cappuccino, made of animal laboratory studies have shown that calorie restriction can prolong life.

Rafael Cabo and his team are studying whether to use drugs caloric restriction, can also play the same effect.

Metformin in type 2 diabetes is the most widely used prescription drugs, type 2 diabetes occurs mainly in people over the age of 40.

It is also used to treat metabolic syndrome, it is a kind of diabetes, hypertension and obesity combined illnesses.

Made in the past experimental results show that metformin can extend a simple organisms such as worms lifetime, but by the flies and mammals are not the same as the experimental results.

The results are encouraging

Rafael cabo team to middle-aged male mice with different doses of metformin, we found that low doses of metformin not only extended the life of mice 5%, and delayed the onset of age-related diseases time.

However, use of high doses of metformin, but harmful, it will shorten the life of the mouse.

Cappuccino said Dr. unclear whether the use of low-dose metformin to prolong human life can also play the effect, so it needs to be more research and clinical trials.

He added that the results of this study are encouraging, at least you can prove that a good diet and exercise is certainly helpful for health and longevity.

Newcastle University professor Searle said Tom Kirkwood, metformin is an effective treatment for metabolic control in type 2 diabetes.

The medical profession has long been known to control mice metabolism, can extend their life and postpone age-related diseases.

However, it is unclear that metformin in mice the role, whether in humans also occur.

Source: www.bbc.co.uk


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